For more than 35 years, the Behavioral Pharmacology Research Unit (BPRU) at the Johns Hopkins University School of Medicine has been a leading clinical research and research training program applying behavior analysis methods to the study and treatment of substance use. BPRU research has used the perspective and methodology of behavior analysis to study substance use and abuse as operant behavior that is influenced and/or controlled by its context and consequences. Human laboratory studies have examined the discriminative and reinforcing effects of drugs, examining influences on drug self-administration, choice behavior, and other indices of drug abuse liability. Outpatient therapeutic trials have integrated incentive-based behavior therapies with pharmacotherapies to assess their individual and interactive contributions to outcome. The most enduring contribution of BPRU is its National Institutes of Health-supported postdoctoral research training program. With more than 100 graduates, the program has provided a research training and scientific productivity foundation for generations of scientists in the substance use and human behavioral pharmacology fields.  

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